ALLERGY AND OTHER HYPERSENSITIVITIES
Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1
Mast cell multistep IgE-desensitization is a time- and dose-dependent process.
Desensitization uncouples signal transduction and FcεRI/IgE/Ag internalization.
Silencing SHIP-1 impairs desensitization.
IFN-Induced Protein with Tetratricopeptide Repeats 2 Limits Autoimmune Inflammation by Regulating Myeloid Cell Activation and Metabolic Activity
Ifit2 deficiency confers susceptibility to autoimmune inflammation.
Ifit2 deficiency impairs myelin debris clearance and remyelination.
Metabolic profiles of myeloid cells and microglia are altered without Ifit2.
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction
The liver microenvironment in AIH and dnAIH is enriched with HERV1-env.
HERV1-env induced loss of Treg suppressor function in dnAIH.
Our results, to our knowledge, reveal a novel mechanism by which HERV1-env induces Treg dysfunction.
CLINICAL AND HUMAN IMMUNOLOGY
The peripheral immune cell profiles of gout are uncovered by CyTOF.
Subsets of CCR4 and OX40 dual-positive immune cells contribute to gout pathology.
CCL17/CCL22-CCR4 axis plays a crucial role in the pathogenesis of gout.
First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα
OSE-127 infusion shows lack of significant lymphopenia in healthy volunteers.
OSE-127 infusion demonstrates lack of serious adverse events in healthy volunteers.
OSE-127 induces dose-dependent inhibition of IL-7 consumption by target cells.
IMMUNOTHERAPY AND VACCINES
Identification of a Novel Keto Sugar Component in Streptococcus pneumoniae Serotype 12F Capsular Polysaccharide and Impact on Vaccine Immunogenicity
Partial Sug substitution was identified in S. pneumoniae serotype 12F polysaccharide.
S. pneumoniae vaccines including serotype 12F contain little to no Sug.
Vaccine-induced Abs elicit killing of 12F strains with varying Sug levels.
INFECTIOUS DISEASE AND HOST RESPONSE
An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection
Cytokine-producing, monocyte-derived macrophages are readily infected by M-CoV.
Type I IFNs curtail viral replication and sustain proinflammatory macrophages.
IFNAR deficiency leads to dysregulated immune phenotypes and immunopathology.
INNATE IMMUNITY AND INFLAMMATION
Duck MARCH8 Negatively Regulates the RLR Signaling Pathway through K29-Linked Polyubiquitination of MAVS
Duck MARCH8 negatively regulates the RLR signaling pathway.
Duck MARCH8 interacts with MAVS and degrades it in a proteasome-dependent manner.
Duck MARCH8 catalyzes the K29-linked polyubiquitination of MAVS at Lys 398.
The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases
The tyrosine kinase inhibitors (TKIs) act as agonists for the NLRP3 inflammasome.
The TKIs exhibit off-target activity against c-Src, Fgr, and Fyn.
Hypoactivity of c-Src, Fgr, or Fyn stimulates the NLRP3 inflammasome activation.
Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein
lncRNA U90926 is upregulated in TLR-stimulated macrophages.
U90926 contains a translated ORF that encodes a secreted protein.
U90926 knockout mice are more susceptible to endotoxic shock.
CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction
CXCL16 aggravates cardiac injury in MI mice.
CXCL16 induces Ly6Chigh monocyte recruitment by production of CCL4 and CCL5.
The CXCL16/CCL4,CCL5/Ly6Chigh axis promotes heart damage after MI.
Regulation of Mesenchymal Cell Fate by Transfer of Active Gasdermin-D via Monocyte-Derived Extracellular Vesicles
Active GsdmD is transferred from monocytes to fibroblasts via extracellular vesicles.
Transfer of active GsdmD promotes caspase-independent fibroblast death.
GsdmD-independent cIAP-2 induction in recipient fibroblasts contributes to cell death.
On the cover: Mouse organotypic cerebellar slices from Ifit2−/− mice costained with myelin basic protein (green) and axonal marker NF200 (red) during the process of remyelination. Kim, D., N. K. Rai, A. Burrows, S. Kim, A. Tripathi, S. E. Weinberg, R. Dutta, G. C. Sen, and B. Min. 2023. IFN-induced protein with tetratricopeptide repeats 2 limits autoimmune inflammation by regulating myeloid cell activation and metabolic activity. J. Immunol. 210: 721–731.
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