PILLARS OF IMMUNOLOGY
ANTIGEN RECOGNITION AND RESPONSES
Immunogenicity threshold affects the CTL responses to the linked nonimmunogenic and subdominant Ags.
Congenic marker Ags are immunogenic when linked to cells with low immunogenicity.
CLINICAL AND HUMAN IMMUNOLOGY
APCs from type 1 diabetes patients have high levels of MHCII–CLIP.
The high levels of MHCII–CLIP are not due to altered HLA-DM or HLA-DO levels.
Type 1 diabetes patients with residual C-peptide have higher levels of DM.
We characterized safety and immune activation of three TLR agonists in rhesus macaques.
TLR7 (2BXy) and TLR4 (LPS) agonists elicit transient but distinct immune activation.
BCG administered i.v. elicits prolonged innate and adaptive immune responses.
RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function
RGS1 is upregulated in Tregs in tumors and inflammatory sites.
RGS1-deficient Tregs are less suppressive, more glycolytic, and less autophagic.
IL-10+ Foxp3neg cells infiltrate the kidneys during GN.
Renal IL-10+ Foxp3neg cells express the transcriptional profile of Tr1 cells.
Renal Tr1 cells are suppressive and protect in experimental GN.
IMMUNOTHERAPY AND VACCINES
The microbiome is a significant regulator of nucleic acid vaccine immunogenicity.
Presence of the microbiome enhances CD8+ T cell responses to mRNA LNP immunization.
The microbiome suppresses IgG and CD4+ T cell responses to DNA prime immunization.
INFECTIOUS DISEASE AND HOST RESPONSE
Edwardsiella piscicida infection inhibits humoral immune responses in turbot.
NITR12 plays a critical role in regulating perforin production in NK cells.
Perforin production from NK cells mediates IgMhi B cell killing.
INNATE IMMUNITY AND INFLAMMATION
Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation
FBXW7 deficiency in DCs alleviates IMQ-induced skin inflammation.
FBXW7 mediates the ubiquitination and degradation of SUV39H2.
FBXW7 reduces the level of H3K9me3 at the Il23a promoter.
PM2.5 exposure mediates progression of pulmonary fibrosis.
PM2.5 induces recruitment of inflammatory Ly6Chi monocytes.
BAL cells in mice have a mixed phenotype in AE-PF.
Complement activation is shaped by Ag density and Ab hinge length.
Unique IgG2 polymorphism shows less efficient complement activation.
Cellular context affects CDC independently of known complement regulators.
Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats
C3aR1 antagonist alleviates paclitaxel-induced mechanical allodynia.
C3aR1 antagonist reduces paclitaxel-induced macrophage expansion in DRG.
C3aR1 antagonist suppresses TRPV4 upregulation and DRG neuron hypersensitivity.
On the cover: Treatment of paclitaxel induces expansion of both Cx3cr1+ and Ccr2+ macrophages in the mice lumbar dorsal root ganglia. The expansion can be suppressed by administration of complement receptor C3aR1 antagonist, SB290157. Xu, J., P. Huang, B. Bie, Y. Dai, S. Ben-Salem, N. Borjini, L. Zhang, J. Chen, M. Olman, J. Cheng, and F. Lin. 2023. Complement receptor C3aR1 contributes to paclitaxel-induced peripheral neuropathic pain in mice and rats. J. Immunol. 211: 1736–1746.
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