Cutting Edge: CCR8 Signaling Regulates IL-25– and IL-33–Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function
CCR8 facilitates IL-25–induced skin and lung ILC2 increase and production of IL-13.
CCR8 regulates IL-33–responsive skin ILC2 increase and production of IL-13/IL-5.
CCR8 controls IL-25–induced ILC2 skin and lung homing and IL-33–induced skin homing.
Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages
IL-6 and TGF-β signaling induces CXCR5 expression in Bach2-deficient CD4+ T cells.
IL-6 increases Bach2 at protein but not mRNA levels in a STAT3-dependent manner.
IL-6/STAT3 controls Tfh versus Th17 differentiation via an incoherent feedforward loop.
Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis
Serpine1 inhibits EAE in a T cell–dependent manner.
Serpine1 is upregulated in Th1 cells and inhibits their pathogenicity.
Serpine1 promotes expression and function of the Th1-specific inhibitory receptor Tim-3.
ANTIGEN RECOGNITION AND RESPONSES
LKB1-mediated SIK activation regulates HDAC7 stability.
HDAC7 stabilization correlates with epigenetic restriction of cytokine loci.
Inhibition of this pathway epigenetically poises cells for enhanced cytokine recall.
CLINICAL AND HUMAN IMMUNOLOGY
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease
GLP-1R agonists attenuate ex vivo human platelet activation and proinflammatory mediators.
GLP-1R agonists target platelets/platelet-dependent airway inflammation in an AERD model.
The GLP-1R axis may regulate platelet-mediated inflammation in asthma.
TRAF6 and TRAF2/3 Binding Motifs in CD40 Differentially Regulate B Cell Function in T-Dependent Antibody Responses and Dendritic Cell Function in Experimental Autoimmune Encephalomyelitis
The TRAF2/3 and TRAF6 binding motifs of CD40 are critically involved in EAE induction.
Both motifs are involved in priming pathogenic T cells by DCs.
The TRAF2/3 motif, but not the TRAF6 motif, is required for TD antibody responses.
INFECTIOUS DISEASE AND HOST RESPONSE
HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection
HOIL1 restricts early intestinal replication and systemic spread of C. rodentium.
HOIL1 functions partly in myeloid cells to limit morbidity and systemic spread.
HOIL1 promotes ILC3 expansion and IL-22 expression during C. rodentium infection.
INNATE IMMUNITY AND INFLAMMATION
Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG
Oxidative stress induces E-selectin expression by downregulation of ERG.
ERG represses the E-selectin promoter activity through the −127 ERG binding motif.
ERG decreases oxidative stress–induced monocyte-endothelial adhesion.
Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1
NLRX1 functions as a mammary tumor suppressor when expressed in host cells.
NLRX1 exacerbates mammary tumor progression when expressed in 4T1 cells.
NLRX1 augments 4T1 aggressiveness through regulation of multiple cancer hallmarks.
Not all mice respond to immune checkpoint therapy.
We correlate tumor-infiltrating lymphocytes with checkpoint therapy success.
Regressing mice have increased T cells and decreased macrophages/monocytes.
NOVEL IMMUNOLOGICAL METHODS
Cold Mechanical Isolation of Placental Macrophages as a Method to Limit Procedure-Induced Activation of Macrophages
Cold mechanical isolation versus enzymatic digestion reduces macrophage activation.
Limiting isolation procedure–induced cell activation improves analysis reliability.
On the cover: The image shows double-immunofluorescent staining of CD31 (red)/E-selectin (green) on the lung tissue of mice treated with PBS. DAPI (blue) was used as a nuclear counterstain. CD31 expression is detected, but E-selectin expression is absent on the endothelium of lung vasculature in the control group of mice. Zhang, J., S. Zhang, S. Xu, Z. Zhu, J. Li, Z.Wang, Y. Wada, A.Gatt, and J. Liu. 2023. Oxidative stress induces E-selectin expression through repression of endothelial transcription factor ERG. J. Immunol. 211: 1835–1843.
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