Infection Dynamics, Pathogenesis, and Immunity to SARS-CoV-2 in Naturally Susceptible Animal Species
ANTIGEN RECOGNITION AND RESPONSES
Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation of PLGA Microsphere–Encapsulated Antigen and a Synthetic Long Peptide In Vitro
We investigated cross-presentation by APCs with homozygous KO for Sec22b and Stx4.
To our knowledge, this is the first study directly examining the role of Stx4 in cross-presentation.
KO of both Sec22b and Stx4 did not have major impact on the cross-presentation of tested Ags.
The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid
Anti-NC16A IgEs recruit eosinophils in experimental BP through the eotaxin-1/CCR3 axis.
Eosinophil-derived MMP-9 mediates tissue injury in experimental BP.
The eotaxin-1/CCR3 axis and MMP-9 are candidate therapeutic targets in BP.
CLINICAL AND HUMAN IMMUNOLOGY
Baseline Abs to respiratory viruses are lower with higher COVID-19 severity.
Abs to nonrespiratory viruses are not different between severity groups.
Titers to seasonal coronaviruses do not predict longitudinal SARS-CoV-2 titers.
Mechanism of TLR4-Mediated Anti-Inflammatory Response Induced by Exopolysaccharide from the Probiotic Bacillus subtilis
B. subtilis EPS inhibits Ag-specific T cell proliferation.
EPS induces inhibitory BMDCs by activating TLR4 and the IDO/kynurenine/AhR circuit.
TLR4 activation by EPS does not induce proinflammatory cytokines.
INNATE IMMUNITY AND INFLAMMATION
Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury
The absence of sIgM is associated with increased anti-cardiolipin IgG levels.
Higher anti-cardiolipin IgG associates with worse injury in Adriamycin nephropathy.
IgG from female sIgM−/− mice binds to injured kidney cells.
EXPRESSIONS OF CONCERN
On the cover: Photomicrograph of lung from white-tailed deer experimentally infected with Mycobacterium bovis. High magnification (×40) of granuloma composed of macrophages with abundant foamy cytoplasm and a large multinucleated giant cell containing a single acid-fast bacillus. Boggiatto, P. M., C. R. Kanipe, E. J. Putz, S. C. Olsen, and M. V. Palmer. 2023. Wildlife immune responses to Mycobacterium bovis and to bacille of Calmette–Guerin. J. Immunol. 211: 1173–1179.
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